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The study was undertaken to assess the protective effect of Spirulina fusiformis extract against Rosiglitazone induced osteoporosis and pharmacodynamic effects of Rosiglitazone with Spirulina in treating hyperglycemia and hyperlipidemia of insulin resistance rat. The findings suggested that combination therapy of Rosiglitazone with Spirulina reduced the risk of Osteoporosis in insulin resistance rats. Additionally, Spirulina complemented the anti hyperglycemic and anti lipidemic activity of Rosiglitazone.