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Abstract: Despite the development of effective antiemetic drugs, nausea and vomiting remain the main side effects associated with cancer chemotherapy. Acupressure at the P6 point is a value-added technique in addition to pharmaceutics. The study was undertaken with the objectives to assess the effect of acupressure on the relief of chemotherapy induced nausea and vomiting among cancer patients. Quantitative research approach was used. The sample of 40 subjects was randomized into two groups: Experimental and control group. Using Multinational Association of Supportive Care in Cancer anti-emesis tool, the reduction of chemotherapy induced nausea and vomiting was measured and comparison made between two groups to see the effectiveness of acupressure on relief of chemotherapy induced nausea and vomiting. In experimental and control group the mean score of number of times feeling nausea, severity of nausea and number of vomiting episodes during first 24 hrs following chemotherapy (i.e. Acute nausea) was 0.50, 2.2, 0.2 and 0.50, 3.25, 0.55 respectively. This result revealed that there is no statistically significant difference between experimental and control group during day 1st. In delayed nausea i.e. 2-5 days the mean score of number of times feeling nausea, severity of nausea and number of vomiting episodes were 0.4, 2.2, 0.18 respectively in experimental group. Whereas in control group mean score of number of times feeling nausea, severity of nausea and number of vomiting episodes were 0.95, 5.35, 0.45 respectively. It was found to be statistically significant difference between intervention and control groups in number of times feeling nausea, severity of nausea and number of episodes of vomiting.