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Oral lesions in the stomatognathic system in human immunodeficiency virus (HIV)‑infected patients are associated with a series of opportunistic disease that are caused due to immune suppressive state. Oral manifestations are the earliest sign of HIV infection. Here, we are reporting a case of a patient suffering from HIV infection with typical oral manifestations and the effect of treatment for the manifestations after a week. The patient was under highly active anti‑retroviral treatment since 2011.