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Coat color plays an important role in protecting animal from environmental stresses like high temperature, UV etc. Coat characteristics are associated with heat tolerance and performance of animals [1]. The basis of coat color in mammals including cattle is the presence or the absence of melanin pigment (eumelanin and pheomelanin). Melanin is produced by pigment producing cells called melanocytes. This skin pigment is the most important photo-protective factor, since melanin, besides functioning as a broadband UV absorbent, has antioxidant and radical scavenging properties [2]. Bos indicus species of cattle are known to tolerate high environmental temperature better than other exotic breeds that corelates with their dark coat color [3]. However, the exact mechanism of coat color dependent thermo-tolerance is a poorly understood phenomenon. In the absence of a suitable model of skin melanocytes the study on bovine skin was challenging. Establishment of spontaneously immortalized bovine melanocyte cell line is an important step in this direction. The ability to culture bovine melanocytes for multiple passages, offers a potentially useful tool to explore and understand the adaptive mechanism adopted by skin against stressful high temperature. This study assumes greater significance in the context of changing climate towards global warming where knowledge about thermal adaptability of skin and the underlying response mechanism may contribute to endeavours towards proper animal management. The study has developed bovine melanocyte cell line to explain the molecular protection mechanism adopted by melanocytes against heat stress.