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Abstract: The title compound, gliclazide is a second generation anti-diabetic medicine and belongs to the class of oral hypoglycemic sulfonylurea. The crystal and molecular structure analysis of gliclazide were carried out by operating single X-ray diffraction technique for single crystal. It was observed that gliclazide crystallizes in the monoclinic P21/n space group with unit cell dimensions a = 10.804(5) ?, b = 14.309(5) ?, c = 10.989(5) ?, ß = 106.995(5)0, V= 1624.7(12) Å3, and Z=4; calculated density is 1.322 Mg m-3. The value for structure factor was 688 and final R = 0.0405 for 2851 unique reflections. The average bond distance of C-H and N-C types were 0.96(1) ? and 1.3758 ?, respectively. The mean C-Caromatic bond length in p-toluenesulfonyl component of gliclazide structure was 1.374 (3) Å, showing good match with the standard C-Caromatic bond length of 1.40 Å. Both the fused five membered cyclopentane and pyrrol rings of gliclazide were found to exist in a envelop conformation.