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The objective of the present study was to explore the anti-acne activity of herbal drug extracts of curcumin by making complexes with varying concentrations of soya lecithin using the phase inversion technique. The preformulation studies were performed and indicated that using the resultant formulation FIM4 shows the maximum potency outcomes. The characterization and evaluation were carried using Fourier Transform Infrared Spectroscopy (FTIR) and using various parameters such as appearance, texture, pH determination, viscosity, spreadability, stability, drug content, saponification value, irritation, antibacterial activity and in vitro diffusion. From the study, it was concluded that the optimized formulation FIM4 show the best resulting potency with antimicrobial properties.