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Background: The objective of the present study is to evaluate the gastroprotective activity of Paederia foetida L. leaf for gastric ulcer. Methods: The methanol extract of P. foetida L. leaves at two different dose levels was investigated for gastroprotective potential by using Indomethacin-pylorus ligation, alcohol induced and water immersion stress induced model in rats. In vitro DPPH* radical scavenging activity and western blot analysis of stomach tissue from pylorus ligatures rats were also carried out. HPTLC analysis was done to understand the phyto-pharmacological relationship. Results: Methanol extract at a dose level of 100 mg/kg and 200 mg/kg body weight showed 72 and 78 {\%} ulcer protection when compared to negative control whereas reference drug shown 82 {\%} protection in Indomethacin-pylorus ligation model. Further, methanol extract also showed protective effect against 70 {\%} v/v ethanol and stress induced gastric ulcer model. About 84 {\%} protection as compared to cimetidine (85 {\%}) was seen in western blot analysis of stomach tissue from pylorus ligatures rats. HPTLC analysis of methanol extract of P. foetida L. confirmed the presence of $\beta$-sitosterol. In DPPH* radical scavenging activity, the IC{\textless}inf{\textgreater}50{\textless}/inf{\textgreater} value was observed to be 43.52 $\mu$g/ml. Conclusions: These observations established the traditional claim and thus Paederia foetida could be a potent gastroprotective agent for use in future. The gastroprotective activity might be mediated by the Nrf2 mediated antioxidant and anti secretory effects.