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Objective: Urinary tract infections (UTIs) are some of the most common bacterial infections encountered in community and cause of significant morbidity and high medical cost. Escherichia coli is the most common pathogen responsible for the majority of UTI infections. Antimicrobial drugs have been routinely prescribed for the empirical treatment of UTIs which has led to a dramatic increase in antibiotic resistance pattern of E. coli. The aim of the present study was to analyze the multidrug resistance (MDR) patterns of E. coli isolated from UTI patients. Methods: A total of 80 urine samples collected from the patients suspected of having UTI attending Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, were cultured using standard microbiological techniques. Antibiotic susceptibility testing of E. coli was done using minimum inhibitory concentration (MIC). MIC of tetracycline, doxycycline, azithromycin, erythromycin, ciprofloxacin, levofloxacin, ampicillin, amoxicillin, and amikacin was done by agar dilution method. Results: Of the total 46 isolates contributing 33 females and 13 males were confirmed as E. coli. About 51.34% of the female patients belonged to the age group 21-40 years and 53.84% of the male population belonged to 41-80 years were found to be more susceptible to UTI infection. All isolates confirmed as E. coli were found to be MDR. 80% of the isolates exhibited MICs higher than 1000 mg/L against β-lactams. 20% of the E. coli isolates exhibited MICs higher than 1000 mg/L against ciprofloxacin, amikacin, and erythromycin. 23% and 95% of E. coli isolates exhibited MICs