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“Dentofacial medicine and diagnosis” refers to the diagnosis and management of oral diseases. It aims to promote and advance the art and science of oral medicine and diagnosis in dentistry. It includes early diagnosis as well as interpretation of oral manifestations of systemic diseases as well. Since oral health has got a pivotal role for maintaining the overall health of an individual, this special issue highlights the importance of dentofacial medicine for the early diagnosis and treatment planning. However, this particular fact is already known by the general dental practitioners, still it is not a well-practiced entity. This leads to increased mortality as well as morbidity. Henceforth this issue is deemed necessary to highlight few of very important aspects including early clinical diagnosis of oral cancer/pre-cancer, orofacial pain (Including neuralgias), oral lesions and conditions, temporomandibular joint disorders, oral manifestations of systemic diseases, forensic aspect with age estimation, oral psychosomatic disorders etc, . It is believed that the knowledge of this speciality will reduce the global rate of mortality and morbidly of systemic diseases too as these specialists possess knowledge to diagnose oral signs of these systemic diseases such as Tuberculosis, syphilis, AIDS, Blood cancers, Anaemia, Nutritional diseases etc,. In many parts of the world oral medicine and diagnosis is considered to be a major speciality. This is taught to the students as one subject or in collaboration with oral pathology and oral radiology. It is believed that if a dental professional possesses the cutting edge knowledge of oral medicine, it will become easier to diagnose the disease at an earlier stage with better patient compliance. As this thematic issue will offer a forum for international collaboration in the field of oral medicine, the coverage will feature cutting-edge research papers, review articles, case reports, diagnostic image reports, technological developments, invited papers, and technical notes. This issue highlights various clinical as well as radiographic expressions and descriptions of various oral and maxillofacial diseases and disorders so as to aid the dental professionals regarding innovative clinical and imaging technique applications.