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Abstract: Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads. Microstylis muscifera plant has been recommended for its use in number of rejuvenating Ayurvedic formulations. Ever rising demands, lack of natural sources and quantity insufficient to meet the requirements of market for the raw material has lead the manufacturers towards the use of official substitutes recommended by Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH) that has further encouraged them for adulteration of formulations by other substandard/spurious raw drugs. More than 60% Ayurvedic parameters as well as pharmacological actions of Ashtawarga plants do not match with their substitutes hence consumers are forced to pay for the material which has never been used for high cost claimed formulations. The situation is being exploited by manufacturers because regulatory authorities lack the tools (marker compound) needed for identification of authentic plant. So this study was carried out to find marker compound of plant that could help in authentication and regulate adulteration. Present communication presents first report of isolation and characterization of marker compound, 5-O-caffeoylquinic acid from methanolic extract of plant using various analytical techniques and can be used as marker for identification of the plant in market formulations. Isolated compounds from the present study can be used as a chemical marker for identification of this plant as the cost of synthetic compound is very high and industry people cannot add it from outside just to prove the presence of Jeevaka.