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A mild and efficient synthetic route has been developed for the preparation of some biologically important 1-aryl/heteroaryl-5-methyl-1,2,4-triazolo [4,3- α] quinolines in excellent yields. In this approach, various quinolinylhydrazones were ground at ambient temperature using iodobenzene diacetate (IBD) under eco-friendly conditions. Therefore, we report a green, rapid and efficient protocol for the synthesis of triazoloquinoline derivatives. The synthesized compounds were characterized on the basis of their FT-IR, 1H NMR spectral data and by comparing their melting points with those reported in literature. Further all compounds were evaluated for their DNA photocleavage activity and it has been observed that compounds 2a-f, 2h-j and 2l displayed good level of biological potential.