Admissions Open
Admissions Open
Ferrocenyl substituted heterocyclic compounds have wide range of medicinal approach. The synthesis of ferrocenyl substituted pyrazole is the new concern in these compounds with enhanced biological activities. This work focus on synthesis of ferrocenyl substituted pyrazoles via novel route. The synthesis of 1-phenyl-3-ferrocenyl-pyrazole was investigated involving Friedel Crafts Acylation like reaction conditions. The reaction proceeded through three stages using addition cyclo-condensation of acetyl ferrocene with phenyl hydrazine followed by cyclization using cyclizing reagent iodine in presence of NaHCO 3. Individual product separated out having excellent yield (83%). Ferrocenyl substituted pyrazoles were characterized by spectroscopic methods (1 H NMR, IR, GC-MS) and their biological properties have been screened.