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Food demand is expected to increase substantially between 59 and 98% by 2050; therefore, to increase the crop production is inevitable in the next 30 years to meet the needs of an ever-increasing human population. This must be accomplished without endangering the environment or human health. Among various pests that impact crop production, weeds are nuisance plants that reduce crop yield by interfering with crop growth in many ways. One of the strategies to control these weeds has been the use of chemical herbicides, which are not safe for environment and human health. The hazardous effects caused by the herbicides have provided a strong impetus for the development of innovative weed control strategies. One of such strategies has been to adopt recommended biological practices for crop protection from weeds. The idea of using plant pathogens to manage devastating weeds has attracted considerable interest among weed scientists and plant pathologists. The application of bacteria, fungi, and viruses to achieve this goal has gained momentum during last two decades. Thus, objective of this review was to evaluate critical issues in the development of effective bioherbicides and discuss the underlying science, the art of formulation and fermentation, and the commercial aspects of bioherbicide production and marketing.