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The presence of eosinophilic Toto bodies in oral lesions could be found in a variety of situations and sometime may present a challenge to the pathologist. We present three case reports where the oral biopsy was taken from the gingival region of a 30-year-old female, a 32-year-old male patient and another from the buccal mucosa of a 67-year-old male patient. Histopathologically, the three cases were finally diagnosed as pyogenic granuloma and moderately differentiated squamous cell carcinoma with the presence of clusters of Toto bodies in the upper spinous layer of stratified squamous epithelium.