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Alzheimer’s disease is a result of unexpected mix of epigenetic, hereditary, and certain ecological elements. It is one of the most complex neurodegenerative problems in human being. The restorative methodologies to overcome the symptoms still a long way from satisfactory. There is subsequently an utmost need to investigate elective speculations during beginning of this neurodegenerative problem. The current review designed to work out endogenous and exogenous sources of formaldehyde and its correlation to Alzheimer’s disease. The current manuscript work encompassed utilization of various open web databases including Sci-Hub as search tools for unique and audit reviews from proficient social orders. In cerebrum tissues, rise of formaldehyde may lead to significant progress in Alzheimer’s disease development, including diverse systems. An increase in degree of intracranial formaldehyde was found in single infusion of methanol and demonstrates oxidation of formaldehyde to methanol in brains of non-human primates. It reveals connections of methanol’s harmfulness in terms of its produce as formaldehyde and noticed as profound corrosives in brain. The causal connections and interconnected pathways including formaldehyde to epigenetics, microRNA and hereditary molecules along β-amyloid, tau protein, changes in histone, assembly of chromatin, misfortune, and methylation of histone. Consistent investigation during current review leads advancement and progress of Alzheimer’s disease correlates to epigenetics and cerebral formaldehyde may furnish a new understanding in management of Alzheimer’s disease and possible restorative targets. Taking this into account, zeroing inhibitors could be one of the most encouraging methodologies for planning and creating drugs against AD.

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