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There has been an intricate link of the gut microbiota to communicate with the brain and further modulating the behaviour of an individual governing homeostasis. Metabolic activity of the microbiota is considered to be relatively constant in healthy individuals despite differences in the composition of microbiota. The metabolites produced by gut microbiota and their homeostatic balance is perturbed as a result of neurological complications. Therefore, it is of paramount importance to explore the link of gut-microbiota with the brain function and behaviour through neural, endocrine, and immune pathways. Current review focuses upon the impact of altered gut microbiota on the brain functions and how does the modulation of the microbiome by use of probiotics, prebiotics, and synbiotics might prove beneficial in the prevention and/or treatment of neurological disorders. One has to carefully understand the complex mechanisms underlying the gut-brain axis so as to use the gut microbiota as a therapeutic intervention strategy in the neurological disorders.