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Healthcare encompasses the trinity of teaching, research, and patient care that necessitates the proper management of biomedical waste (BMW) generated during these activities. In recent years, with the rise in public and private healthcare establishments, India is likely to generate about 775.5 tons of medical waste per day by 2022. A joint study conducted by industry body The Associated Chambers of Commerce and Industry of India and Velocity suggests that medical waste is expected to grow at a compounded annual growth rate of about 7%. The seemingly endless stream of BMW has become a topic of global concern and implications. It is not only the subject of humanitarian concern but it has far-reaching effects on the environment also. BMW is a potential health hazard to the healthcare workers, public, and flora and fauna of the area. The Environment Protection Act 1986, the BMW (Management and Handling) Rules in July 1998, subsequently revised in 2011, and now the “BMW Management Rules, 2016” are an attestation to the commitment of the Government of India to ensure safe and proper disposal of allopathy and nonallopathy (Ayurveda, Siddha, Unani, or Homeopathy) BMW. The present BMW guidelines are based on the guiding principles of the World Health Organization, The Basel Convention on Hazardous Waste (1989), The Bamako Convention (1991), The Stockholm Convention on Persistent Organic Pollutants (2001), and The Minamata Convention on Mercury (2013). Despite our two-decade-old history of implementing BMW management guidelines, there have been innumerable incidents of mismanagement of BMW. The Hepatitis Outbreak in Modassa, Gujarat (India), 2009 is one of the major episodes that drew attention to the issue of unsatisfactory BMW management in the country. “Safe and effective management of waste is not only a legal necessity but also a social responsibility. Lack of awareness, commitment, concern, and cost factor are some of the reasons for unsatisfactory management of BMW.”