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Objective: The aim of this study was to evaluate the effect of polyvinylpyrrolidone-iodine (PVP-I) 2 % as hemostyptic when used as an irrigant in low concentration during surgical procedures. Methods: We selected 100 healthy patients who needed routine dental extraction for this study. Patients were divided into two groups: the treatment group (n = 50) and the control group (n = 50). The alveolar sockets of patients in the treatment group were irrigated using PVP-I (2 %, w/v) following routine dental extraction, whereas those of the control group were irrigated using normal saline (sodium chloride 0.9 %, w/v). Spontaneous cessation of bleeding from the socket following irrigation was considered as significant hemostasis. After irrigation, the sockets were compressed with digital pressure. Data were analyzed using SPSS software. Results: Both groups were matched for age (t test, p > 0.05 %). Average bleeding control time in the PVP-I (2 % w/v) group was 135.72 ± 11.348 s and in the saline group 168.78 ± 23.661 s (which was statistically significant at p < 0.001). Out of 100 patients, 42 % were female and 58 % were male; both groups were matched for gender (χ2, p = 0.224). Conclusion: PVP-I significantly (p < 0.001) controlled bleeding as compared with saline, suggesting that PVP-I irrigation acts as a hemostyptic.