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Abstract
1-(2-Arenethyl)-3, 5-dimethyl-1 H -pyrazoles ( 4a-g ) were obtained by Wolff-Kishner reduction of 2-(3,5-Dimethyl-1 H -pyrazol-1-yl)-1-arylethanones ( 3a-g ). The synthesized com- pounds were characterized by analyzing their IR, 1 H, and 13 C-NMR spectral data. Interme- diates ( 3a-g ) were synthesized by the solid phase reaction of 3, 5-dimethylpyrazole with different substituted phenacyl bromides under basic condition by adopting reported pro- cedure. All synthesized compounds were screened in vitro for their anti-bacterial poten- tial against four bacterial strains and it was found that the compounds 4c and 4g bear- ing methoxy and nitro group, respectively, exhibited good level of inhibitory potential which was about 25% of the standard drug, Ciprofloxacin- against Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa bacterial strains. Further, DNA photocleavage ability was also explored and it was observed that compounds bearing halogen group ( 4d, 4e and 4f ) displayed good DNA photocleavage activity.