Admissions Open
Admissions Open
Inflammation is a major cause of progression of several dreadful diseases such as cancer, cardiovascular and neurodegeneration. It has been found that each year the number of infected patients with inflammatory diseases is increasing rapidly. Due to the lack of promising therapeutic approaches, the chances are there that inflammatory disorders will become the number one to cause mortality in patients. In the past decade, the drug resistance against existing drug molecules has been observed that stimulated the need to develop or find alternative therapies. Epidemiological studies have shown the promising role of plant secondary motabolites in the prevention of inflammation and associated disorders. There are a diverse group of biological molecules such as flavonoids or polyphenolic compounds that are known to possess promising anti inflammatory activity. Broad spectrum of the mode of actions of natural metabolites has attributed them a wide therapeutic application. Further, chronic inflammation is found to be associated with a variety of genes that enhance the inflammatory signaling pathways leading to the expression of inflammatory cytokines and chemokines. It has been reported that polyphenolic compounds, present in fruits, tea, and in other vegetables may not only suppress the production of pro-inflammatory cytokines but may also upregulate their natural cellular inhibitors. Studies have suggested the utilization of natural polyphenoilc compounds instead of using steroidal anti-inflammatory drugs to possibly suppress the intensity of inflammation in various chronically inflammed patients with inflammatory diseases.